Cannabidiol (CBD) is one of the 60 naturally occurring cannabinoids found in a cannabis plant. Unlike Tethrahydocannabdiol (THC), known for its psychoactive elements, CBD is non-intoxicating and can offer relief and benefits without the disconcerting feelings of lethargy or dysphoria. The majority of information on the Internet today, highlights the potential benefits of CBD, but are there known CBD oil effects that users should be aware of and is there a limit to how much CBD one person can safely consume?
Potential CBD Oil Effects
Multiple studies, published as early as 1980, suggest that CBD has minimal side effects and is overall safe for consumption. Nonetheless, consumers should be made aware of any known, potential drawbacks of something you are putting in your body. Below, we discuss the findings from each recorded study and review on the safety and known side effects of CBD.
1980 Study in Pharmacology
On January 3, 1980, Pharmacology published their findings conducted during a study in which they tested eight healthy volunteers and 15 patients with epilepsy, looking at the side effects of CBD when consumed daily for a month. Their reported conclusions were, ‘All patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination.’
International Journal of Neuroscience
In 1986, oral doses, ranging from 100 to 600 mg per day of cannabidiol were given to 5 patients with dystonic movement disorders. In addition to recording specific benefits, this study also uncovered mild side effects of CBD such as hypotension, dry mouth, psychomotor slowing, lightheadedness, and sedation. It is also noteworthy, that during this study 2 patients given CBD in doses over 300 mg per day seemed to aggravate their Parkinson’s symptoms. Yet in 2014 a separate paper described how CBD significantly improves the lives of those with Parkinson’s disease.
Safety and Side Effects of Cannabidiol
Most recently in 2011, a review on the safety and side effects of cannabidiol, found that CBD might interfere with the hepatic drug metabolism, alteration of in vitro cell viability, decreased fertilization capacity or the reduced activity of p-glycoprotein. Has a pharmacist or doctor ever told you not to drink or eat grapefruit while taking a prescription medication? Grapefruit and CBD have a similar effect on P450, an enzyme found in the liver, which metabolizes different kinds of drugs in the human body. If taken in large doses, CBD can inhibit the metabolizing properties of P450, temporarily neutralizing the effects of other medicinal products in the body’s system. This side effect is also responsible for why cannabidiol counteracts the effects of THC.
2006 Study Argentinian Study
In 2006 a group of scientist hypothesized that there are cannabinoid receptors in human’s salivary glands. In fact, their hypothesis was correct, which is most likely the reason that one of the previously discovered side effects of CBD is what’s commonly known as cotton-mouth. When CBD interacts with the endocannabinoid system, it inhibits the secretion of saliva, thus leaving some users with a dry sensation in their mouth.
Can you overdose on CBD?
Cannabidiol and other cannabinoids are known to be non-toxic, with no known fatal overdose levels ever reported. The previously mentioned study from 2011 indicated that chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. The Department of Health and Human Services states, ‘no signs of toxicity or serious side effects have been observed following chronic administration of cannabidiol to healthy volunteers (Cunha et al., Pharmacology 21:127-185, 1980), even in large acute doses of 700 mg/day (Consroe et al., Pharmacol, Biochem, Behav. 40:701-708, 1991).’
As you can see, there is evidence that supports CBD being a safe substance with minor side effects. We want to hear from you. Have you ever experienced side effects from using CBD? Please leave comments below.
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Beginning in the 1980’s marijuana cultivators worldwide were on one mission: to grow the most potent, most psychoactive cannabis on the market. Because of this, plants that were rich in other cannabinoids like CBD (THC’s non-intoxicating counterpart) were considered “garbage crops.” That was the case until news about CBD’s potential exploded on the cannabis scene, suddenly destigmatizing the “stoner-centric” industry.
Today “CBD Oil” is searched on Google an average of 200,000 times each month. On the cusp of conjuring its own revolution, this hot product is catching the attention of millions of people all over the world, who are curious about the benefits of cannabidiol paired with the ease of consumption, accurate dosing, and overall effectiveness that CBD oil offers.
So how is CBD oil made and what is important to know before choosing a product? We answer these questions and more below.
How is CBD Oil Made?
CBD oil can be extracted from marijuana plants (which are typically high in THC) or industrial hemp plants. For legality purposes, The CBDistillery uses the stalks and stems derived from non-GMO, pesticide free, industrial hemp plants.
Hemp plants are grown similarly to marijuana plants but are typically tall and thin and compared to marijuana plants which are short and wide. Once cultivated, hemp plants are lifted from the ground and brought to an extraction facility. Ethanol and C02 extraction are two commonly used methods for extracting CBD and two of the cleanest ways to extract cannabidiol for human consumption. CO2 extraction, a popular extraction method typically used when extracting smaller quantities of hemp, involves filtering hemp plants through a series of chambers that control temperature and pressure. When different temperatures and units of pressure are applied to cannabis plants, this sophisticated system is able to isolate cannabinoids at a 90% efficiency.
An alternative method is ethanol extraction which involves introducing the solvent ethanol to the hemp plant in order to separate and isolate cannabinoids. Unlike CO2 extraction, on is able to produce a very high volume of full spectrum extract with this method. Ethanol also removes unwanted components such as chlorophyll from dried hemp.
Once this potent oil is extracted, it is mixed with a carrying oil such as aforementioned MCT Coconut oil.
What is Full Spectrum Oil?
Some CBD oil products on the market are limited to CBD explicitly while others advertise their product as “full spectrum.” The CBDistillery’s CBD oil is one of the full spectrum products containing other essential cannabinoids like CBN and CBC.
Why do we include these other compounds? A wider range cannabinoid spectrum is important because it encourages the entourage effect, which helps to stimulate the endocannabinoid system and the molecular interaction. Simply put, the entourage effect is the scientific belief that cannabinoids have greater therapeutic benefits when acting together rather than acting as a single molecule.
How is CBD Oil Used?
One of the reasons CBD oil is such a highly sought after product is because of its ease of use. Cannabidiol oil is meant to be consumed orally and most often used sublingually. Sublingual administration involves placing drops under your tongue and holding it there for several seconds before swallowing. Using CBD sublingually is the second fastest form of consumption (the first being vaping or dabbing). Some find the taste of CBD oil very appealing while others do not prefer the hemp flavor. For those who are not fond of the taste, drops can be placed in a beverage like orange juice or foods like salad dressing to dilute the taste. *The CBDistillery is unable to make dosage recommendations and suggest doing further research at ProjectCBD.org.
Looking for more information on The CBDistillery Full Spectrum tinctures? Check out our YouTube video below.