Can You Overdose on CBD Oil? Why Not + Potential CBD Side Effects

Cannabidiol (CBD) is one of the 60 naturally occurring cannabinoids found in a cannabis plant. Unlike Tetrahydrocannabinol (THC), known for its psychoactive elements, CBD is non-intoxicating and can offer relief and benefits. The majority of information out there highlights the potential benefits of CBD products, but are there any known CBD oil effects that users should be aware of, and is there a limit to how much CBD one person can safely consume?

Can you overdose on CBD?

Cannabidiol and other cannabinoids are known to be non-toxic, with no known fatal overdose levels ever reported. The previously mentioned study from 2011 indicated that chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. The Department of Health and Human Services states, ‘no signs of toxicity or serious side effects have been observed following chronic administration of cannabidiol to healthy volunteers (Cunha et al., Pharmacology 21:127-185, 1980), even in large acute doses of 700 mg/day (Consroe et al., Pharmacol, Biochem, Behav. 40:701-708, 1991).’

Potential CBD Oil Side Effects

Multiple studies suggest that CBD is overall safe for consumption. Nonetheless, consumers should be made aware of any known potential drawbacks of something you are putting in your body. Below, we discuss the findings from each recorded study and review on the safety and known side effects of CBD.

Safety and Side Effects of Cannabidiol

Most recently in 2011, a review on the safety and side effects of cannabidiol, found that CBD might interfere with the hepatic drug metabolism, alteration of in vitro cell viability, decreased fertilization capacity or the reduced activity of p-glycoprotein. Has a pharmacist or doctor ever told you not to drink or eat grapefruit while taking a prescription medication? Grapefruit and CBD have a similar effect on P450, an enzyme found in the liver, which metabolizes different kinds of drugs in the human body. If taken in large doses, CBD can inhibit the metabolizing properties of P450, temporarily neutralizing the effects of other medicinal products in the body’s system.

2006 Study Argentinian Study

In 2006 a group of scientists hypothesized that there are cannabinoid receptors in human salivary glands. Their hypothesis was correct, which is most likely the reason that one of the previously discovered side effects of CBD is what’s commonly known as dry mouth or ‘cotton mouth.’ When CBD interacts with the endocannabinoid system, it inhibits the secretion of saliva, thus leaving some users with a dry sensation in their mouth2.

How Much is Too Much CBD?

CBD dosage is entirely dependent on your biological makeup and tolerance to CBD. Begin with a small dose of CBD and work your way up to a comfortable point. If you don’t feel comfortable with self-dosing (CBD tinctures, vapes, topicals) try a CBD product that has a pre-dosed amount of CBD you prefer (CBD gummies, softgels, capsules). Pre-dosed CBD can be especially useful for first-time users who have never tried cannabidiol products.

As you can see, there is evidence that supports CBD being a safe substance with minor side effects.

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Sources:

1. Bergamaschi, M. (2011). Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent.
2. Prestifilippo, JP. ( 2006, Sep). Inhibition of salivary secretion by activation of cannabinoid receptors.