Why Does Cannabis Affect People Differently?

We recently conducted a survey where we asked CBDistillery™ customers, “what is the primary benefit you received from CBDistillery™ products?” Not to our surprise, we received a variety of answers, no two entirely alike. What immediately sparked my attention, were the comments from customers stating something similar to, “I didn’t get any relief” and “it helped a little but not as much as I’d hoped.” The majority of the feedback we receive from CBDistillery™ customers on a day-to-day basis is how CBD has changed their lives for the better. So why does CBD impact some and not others? Why does cannabis affect people differently?

Cannabis Plant Study

Rafael Mechoulam. Photo Credit

To get some answers, I took to the Internet and found several studies about why cannabis products affect users differently. Apparently, I am not the first person to ask this question. Even the ‘father of THC,’ Rafael Mechoulam was curious about how this newly discovered molecule would affect different people. Thus, one evening he invited over a few of his friends for some cake, which little did they know, was laced with 10mg of pure THC. A few of his friends felt ‘strange, in a different world,’ while some couldn’t stop talking or giggling. While the scientist now understood the cannabis compound, THC does, in fact, cause different reactions, it wasn’t until years later that we would figure out why. Here is a look as to why all cannabis (marijuana or hemp derived) products affect people differently.

Genetics

About 20% of the population has good endocannabinoid genetics. These people were born with a genetic mutation that increases the level of endocannabinoids and levels of anandamide (the so-called bliss molecule) naturally occurring in their system.Cannabis Genetics As a whole, the endocannabinoid system is partially responsible for regulating sleep, appetite, mood, motor control, immune function, pleasure, pain, reproduction and fertility, memory and temperature regulation. When someone consumes cannabis, the cannabinoids, like THC and CBD, replace the naturally occurring endocannabinoids in your body. Thus, if you are among the lucky few that have this genetic mutation, you are most likely less inclined to feel the effects of CBD because your body already naturally produces a similar result.

Men vs. Women

Cannabidiol products affect men and women differently. Research shows that estrogen makes females more sensitive to cannabis. That time of the month? Washington State University found that women are impacted more by THC a day or two before ovulation, because of the peak in estrogen levels.

Men versus Women Cannabis Study

photo credit

Unique Biochemistry

Biochemistry, the study of chemical substances and vital processes occurring in living organisms is yet another explanation as to why people react differently to CBD products. No two individuals have the exact biochemistry make up, which affects the way substances metabolize throughout our system. The health of one’s endocannabinoid system plays a significant role in this. As previously mentioned, the human body naturally produces endocannabinoids. Things like diet, stress, and overall lifestyle influences endocannabinoid levels. When consuming cannabis products, you are increasing endocannabinoid levels. For individuals who have deprived levels, cannabis consumption will most likely produce a favorable experience, whereas someone with healthy endocannabinoid levels might not “feel” the effects of CBD or other marijuana products.

Overall Health

Man exercising upside down

Someone who is using cannabis products to treat symptoms for a disease or disorder is going to have a very different experience than someone using cannabis recreationally. When someone is fighting off an ailment or illness, that individual’s biochemistry and endocannabinoid levels are altered. Thus, when someone with Parkinson’s disease uses a product like CBD oil, the outcome may be feeling “normal” because endocannabinoid levels are replenished. The average person, on the other hand, may use the same product and feel nothing at all or very different effects.

Tolerance

It is relatively well-known that over time and continued use, one will most likely build a tolerance to THC. Yet, in one study conducted in 2011, findings suggest that one may not build a tolerance to CBD.  However, more research needs to be done to prove this theory.
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What Are The Side Effects Of CBD?

Cannabidiol (CBD) is one of the 60 naturally occurring cannabinoids found in a cannabis plant. Unlike Tethrahydocannabdiol (THC), known for its psychoactive elements, CBD is non-intoxicating and can offer relief and 25mg CBD Capsules from Hemp CBD Oil at The CBDistillerybenefits without the disconcerting feelings of lethargy or dysphoria. The majority of information on the Internet today, highlights the potential benefits of CBD, but are there known side effects that users should be aware of and is there a limit to how much CBD one person can safely consume?

The Potential Side Effects of CBD

Multiple studies, published as early as 1980, suggest that CBD has minimal side effects and is overall safe for consumption. Nonetheless, consumers should be made aware of any known, potential drawbacks of something you are putting in your body. Below, we discuss the findings from each recorded study and review on the safety and known side effects of CBD.

1980 Study in Pharmacology

On January 3, 1980, Pharmacology published their findings conducted during a study in which they tested eight healthy volunteers and 15 patients with epilepsy, looking at the side effects of CBD when consumed daily for a month. Their reported conclusions were, ‘All patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination.’

International Journal of Neuroscience

In 1986, oral doses, ranging from 100 to 600 mg per day of cannabidiol were given to 5 patients with dystonic movement disorders. In addition to recording specific benefits, this study also uncovered mild side effects of CBD such as hypotension, dry mouth, psychomotor slowing, lightheadedness, and sedation. It is also noteworthy, that during this study 2 patients given CBD in doses over 300 mg per day seemed to aggravate their Parkinson’s symptoms. Yet in 2014 a separate paper described how CBD significantly improves the lives of those with Parkinson’s disease.

Safety and Side Effects of Cannabidiol

Most recently in 2011, a review on the safety and side effects of cannabidiol, found that CBD might interfere with the hepatic drug metabolism, alteration of in vitro cell viability, decreased fertilization capacity or the reduced activity of p-glycoprotein. Has a pharmacist or doctor ever told you not to drink or eat grapefruit while taking a prescription medication? Grapefruit and CBD have a similar effect on P450, an enzyme found in the liver, which metabolizes different kinds of drugs in the human body. If taken in large doses, CBD can inhibit the metabolizing properties of P450, temporarily neutralizing the effects of other medicinal products in the body’s system. This side effect is also responsible for why cannabidiol counteracts the effects of THC.

2006 Study Argentinian Study

In 2006 a group of scientist hypothesized that there are cannabinoid receptors in human’s salivary glands. In fact, their hypothesis was correct, which is most likely the reason that one of the previously discovered side effects of CBD is what’s commonly known as cotton-mouth. When CBD interacts with the endocannabinoid system, it inhibits the secretion of saliva, thus leaving some users with a dry sensation in their mouth.

Can you overdose on CBD?

Cannabidiol and other cannabinoids are known to be non-toxic, with no known fatal overdose levels ever reported. The previously mentioned study from 2011 indicated that chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. The Department of Health and Human Services states, ‘no signs of toxicity or serious side effects have been observed following chronic administration of cannabidiol to healthy volunteers (Cunha et al., Pharmacology 21:127-185, 1980), even in large acute doses of 700 mg/day (Consroe et al., Pharmacol, Biochem, Behav. 40:701-708, 1991).’

As you can see, there is evidence that supports CBD being a safe substance with minor side effects. We want to hear from you. Have you ever experienced side effects from using CBD? Please leave comments below.

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The Emergence of CBD Oil

Beginning in the 1980’s marijuana cultivators worldwide were on one mission: to grow the most potent, most psychoactive cannabis on the market. Because of this, plants that were rich in other cannabinoids like CBD (THC’s non-intoxicating counter part) were considered “garbage crops.” That was the case until news about CBD’s potential exploded on the cannabis scene, suddenly destigmatizing the “stoner-centric” industry.

Today “CBD Oil” is searched on Google an average of 200,000 times each month. On the cusp of conjuring its own revolution, this hot product is catching the attention of millions of people all over the world, who are curious about the benefits of cannabidiol paired with the ease of consumption, accurate dosing, and overall effectiveness that CBD oil offers.

So how is CBD oil made and what is important to know before choosing a product? We answer these questions and more below.

How is CBD Oil Made?

CBD oil can be extracted from marijuana plants (which are typically high in THC) or industrial hemp plants. For legality purposes, The CBDistillery uses the stalks and stems derived from non-GMO, pesticide free, industrial hemp plants.

Hemp plants are grown similarly to marijuana plants but are typically tall and thin and compared to marijuana plants which are short and wide. Once cultivated, hemp plants are lifted from the ground and brought to an extraction facility. C02 extraction is not the only extraction method but one of the most popular and cleanest ways when extracting CBD for human consumption. CO2 extraction involves filtering hemp plants through a series of chambers that control temperature and pressure. When different temperatures and units of pressure are applied to cannabis plants, this sophisticated system not only separates the various cannabinoids from each other, but it also can isolate the desired compound for extraction and use. Once this potent oil is extracted, it is mixed with a carrying oil such as aforementioned MCT Coconut oil.

What is Full Spectrum Oil?

Some CBD oil products on the market are limited to CBD explicitly while others advertise their product as “full spectrum.” The CBDistillery’s CBD oil is one of the full spectrum products containing other essential cannabinoids like CBN and CBC.

Why do we include these other compounds? A wider range cannabinoid spectrum is important because it encourages the entourage effect, which helps to stimulate the endocannabinoid system and the molecular interaction. Simply put, the entourage effect is the scientific belief that cannabinoids have greater therapeutic benefits when acting together rather than acting as a single molecule.

How is CBD Oil Used?

One of the reasons CBD oil is such a highly sought after product is because of its ease of use. Cannabidiol oil is meant to be consumed orally and most often used sublingually. Sublingual administration involves placing drops under your tongue and holding it there for several seconds before swallowing. Using CBD sublingually is the second fastest form of consumption (the first being vaping or dabbing).  Some find the taste of CBD oil very appealing while others do not prefer the hemp flavor. For those who are not fond of the taste, drops can be placed in a beverage like orange juice or foods like salad dressing to dilute the taste. *The CBDistillery is unable to make dosage recommendations and suggest doing further research at ProjectCBD.org.

Looking for more information on The CBDistillery Full Spectrum tinctures? Check out our YouTube video below.  

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What Is CBD and How Does It Work?

According to The Hemp Business Journal, over the next three years, the CBD market is predicted to grow by 700%. Yet, in a survey conducted in 2016, only 5% of Americans know what CBD is. For an industry that is supposed to grow exponentially, it sure does seem like the public needs to become more educated on this product. We are here to help!

What is CBD?

Cannabis plants contain 60, naturally occurring, active compounds called cannabinoids. Cannabidiol (CBD) is one of these compounds found in hemp and marijuana plants. Tetrahydrocannabinol (THC) is the most well-known cannabinoid and is associated with marijuana’s psychoactive properties. Unlike THC, CBD does not cause a “high” effect and can offer relief and benefits without the disconcerting feelings of lethargy or dysphoria. How do cannabinoids interact with the human body and why do cannabinoids cause different effects? To answer this question, we must introduce the endocannabinoid system.

The Endocannabinoid System and how CBD works

In the 1980s, President Ronald Reagan poured tens of millions of dollars into a study to prove that marijuana damages the human brain. But, rather than showing how marijuana harms the brain, the Reagan administration ended up subsidizing a series of studies that culminated in the discovery of the endocannabinoid system. The endocannabinoid system (ECS) is a collection of cell receptors and the corresponding molecules (agonists) in the human body. This system helps to regulate sleep, appetite, mood, motor control, immune function, pleasure, pain, reproduction and fertility, memory and temperature regulation. When the ECS is in balance, one experiences homeostasis.

Endocannabinoids are the molecules that act as chemical messengers that bind to cannabinoid cell receptors and tell the body to do certain things. The human body naturally produces endocannabinoids with the help of consuming foods like fatty acids found in nuts and fish. The 60 cannabinoid molecules found in cannabis also have the ability to bind to cannabinoid receptors. Although different cannabinoids (like CBD and THC) cause different effects, it is all through the same system that similar molecular messages are sent throughout the body. Put more simply, the molecules found in cannabis plants aid in the human body’s endocannabinoid system, which is responsible for many vital functions.

What does CBD help to treat?

The CBDistillery™ is legally unable to make medical claims in regards to our products, but would highly suggest doing further research. Here are some great resources:

Project CBD: https://www.projectcbd.org/conditions

PubMed clinical studies: https://www.ncbi.nlm.nih.gov/pubmed/?term=CBD

The statements made regarding CBD (cannabidiol) have not been evaluated by the Food and Drug Administration. The efficacy of these products and the testimonials made have not been confirmed by FDA- approved research. These products are not intended to diagnosis, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product. The Federal Food, Drug and Cosmetic Act requires this notice.

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Sources:

https://www.leafly.com/news/science-tech/what-is-the-endocannabinoid-system

http://www.leafscience.com/2017/03/17/the-endocannabinoid-system-a-beginners-guide/

https://www.projectcbd.org/how-cbd-works

http://herb.co/2016/07/28/endocannabinoid-system-dummies/

https://www.forbes.com/sites/debraborchardt/2016/12/12/the-cannabis-market-that-could-grow-700-by-2020/#568255c34be1

Are All CBD Molecules Created Equally?

Are All CBD Molecules Created Equally?

A look into Hemp derived CBD vs. Marijuana derived CBD

A commonly visited topic in the cannabis industry and with The CBDistillery™ community is the difference between CBD, cannabidiol, derived from hemp versus CBD derived from marijuana. While some canna consumers argue there is no difference between the CBD produced from these two products, others passionately debate that CBD derived from marijuana is superior. So what are the facts? Below we explore the unbiased, scientific data regarding this subject.

What is the difference between hemp and marijuana?

Hemp and marijuana come from the same cannabis species, but are grown for different purposes. Hemp – also called industrial hemp- is one of the oldest plants known to man, dating back to 8000 BC (1). The plant itself is typically tall and thin and cultivated to produce food, oils, paper, other textiles, and high CBD extractions. Marijuana plants, on the other hand, are bred for their psychotropic properties.

The cannabis plant species, which includes industrial hemp, contains 60 known cannabinoid compounds. The levels of THC in cannabis are what legally distinguish which plants are considered hemp and which are considered marijuana. High levels of THC (3 -15%) which is the most well-known compound in cannabis and is the cannabinoid most commonly associated with the plants’ psychoactive properties, is found in higher concentrations in marijuana plants, where as industrial hemp status is given to cannabis plants with THC levels less than .3%.

CBD in hemp plants vs. CBD in marijuana plants

Cannabinoid ratios differ from each cannabis strain. Whereas the marijuana strain in Girl Scout Cookies has high levels of CBG, the Sativa strain Durban Poison is richer in THCV. Neither strain is necessarily better, they just different in cannabinoid ratios. Similarly, hemp is a cannabis strain with typically higher concentrations of CBD, CBG, CBC and sometimes THCV but will always have low levels of THC.

Are all CBD molecules created equally?

The CBD molecule when isolated is the same whether it was derived from marijuana or hemp. Thus, the argument of the CBD molecule being different in marijuana and hemp is a misconception. Franjo Grotenhermen of the International Association of Cannabinoid Medicines famously declared, “CBD is CBD. The human body does not care where the molecule comes from (2).”

To better understand this, think of drinking water from the faucet of your sink or a filtered water bottle. Although the purity of the water might be different, the H2O molecule is consistent.

Similar to the above analogy, what is arguably relevant in the debate between hemp versus marijuana extracts should be the purity and safety of the cannabidiol someone is consuming, regardless of the plant, it is derived from.

The Importance of Extraction Methods

There are various ways of extracting cannabidiol from a cannabis plant, each with their pros and cons. CO2 and ethanol extraction are two of the most commonly used methods. CO2 extraction, for example, uses carbon dioxide under high pressure and extremely low temperatures to extract, preserve, and maintain the purity of the CBD oil. According to ProjectCBD.org, ‘when well done the end product is safe, potent, and free of chlorophyll’ (3). When choosing a CBD product, make sure the company uses a safe solvent and a verified extraction method.

Conclusion

A molecule is a molecule is a molecule. This theory is consistent when it comes to all cannabis products, including CBD products derived from hemp and marijuana plants. It is highly recommended when choosing a CBD product, to look beyond which plant the molecule has been extracted from and consider the potency, safety, and most importantly, the quality which is not impacted by what type of cannabis the molecule came from but rather the purity of the molecule itself.

 

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Sources:

  1. https://www.leafly.com/news/cannabis-101/hemp-101-what-is-hemp-whats-it-used-for-and-why-is-it-illegal
  2. http://www.medicalmarijuanainc.com/cbd-hemp-oil-vs-cbd-medical-marijuana/
  3. https://www.projectcbd.org/cannabis-oil-extraction