CBD Gummies with Melatonin: Are They More Effective?

During sleep, your brain releases a surge of hormones that support multiple aspects of overall health and well-being – cognitive function, immune system support, emotional regulation, and more. Although public awareness of the connections between too little sleep, poor sleep quality, and the increased risk of cardiovascular disease, metabolic dysfunction, and mood disorders has improved over the past decade or so, 36.8% of US adults still report not getting enough sleep, according to data in the CDC’s 2022 Behavioral Risk Factor Surveillance System survey.¹

Instead of turning to OTC or prescribed supplements to help with sleep, many people are turning to more natural ways to improve sleep, including CBD and melatonin. But what happens when you combine the two? Does it lead to better results?

Understanding the Ingredients Separately

What is CBD?

Cannabidiol, or CBD, is a naturally occurring compound in cannabis plants like hemp that has shown promise in supporting health and wellness goals.  According to a 2019 CBDistillery® survey of 1,900 customers, most users reported experiencing increased relaxation, better sleep, and reduced mild or temporary anxiety when taking CBD consistently. And, unlike THC, CBD is non-intoxicating.

What is Melatonin?

Melatonin is a hormone produced by your body to help regulate your circadian rhythm, also known as your sleep cycle. It is produced by your brain in response to darkness, which means natural and artificial sources of light can inhibit its production and release, leaving you with an irregular sleep cycle. Many people rely on OTC melatonin to help them fall asleep and stay asleep.

What Happens When CBD and Melatonin Are Used Together?

Consumers who prefer a more holistic approach to sleep support tend to lean towards gummies infused with melatonin or botanicals like valerian root, passionflower, ashwagandha, and hemp-derived CBD. Melatonin supplements help reset your circadian rhythms. Research into herbs like valerian root, passionflower, and lemon balm suggests that these herbal extracts may exert sleep-promoting properties through interacting with GABA receptors and modulating GABAergic signaling in the brain.² CBD influences the same neurotransmitters while also interacting with CB1 and CB2 – your endocannabinoid system receptors. All of those factors combined create the perfect product to help you sleep better.

Are They More Effective Together?

Research into the combined effects of melatonin and CBD is still in its early stages. However, multiple studies into the effects of CBD have shown potential for improvement in sleep-related conditions and disorders,^3,4 and other studies into melatonin have also shown a positive effect on sleep quality.^5,6

Choosing the Right CBD + Melatonin Gummy

Even a single night of sleeplessness can trigger a chain of events that can cause disruptions lasting days, weeks, or months at a time. If you're tired of feeling physically, mentally, and emotionally depleted because of too little sleep or poor sleep quality, consider adding CBD + melatonin to your nightly routine.

When you choose the sleep-promoting potential of CBDistillery® CBD sleep gummies with melatonin, you can shop with confidence. Our gummies are vegan, made with 100% clean ingredients, and backed by more than 47,000 verified 5-star reviews. All CBDistillery® product labels have a QR code linked to a certificate of analysis for that specific batch – not a batch produced three years ago. And if you're still not quite sure where to begin, consider requesting a personal consultation.  

Not Ready to Try CBD + Melatonin?

If you’re on the fence about melatonin but still on the hunt for more restful sleep and better sleep quality, consider one of our other hemp-derived CBD gummies. Carefully formulated by our expert botanists, these gummies include CBN to help you fall asleep, stay asleep and wake up refreshed without grogginess the next morning.

CBDistillery® shhh+ THC + CBN + CBD Enhanced Deep Sleep Gummies  

CBDistillery® shhh+ distilled THC + CBN Gummies are made to help you get the rest you need to wake feeling refreshed. Combining 15mg of cannabinol (CBN), a cannabinoid well-known for its sleep-promoting potential, and 5 mg of naturally-occurring Delta-9 THC with 75mg of full spectrum CBD, these gummies help you wind down before bed, fall asleep and stay asleep. In a 2023 CBDistillery® study, participants using our gummies with THC and CBN reported sleeping an average of 36 minutes longer per night!

CBDistillery® shhh CBN Isolate Sound Sleep Gummies 

CBDistillery® shhh CBN Isolate Sound Sleep Gummies are our first-ever supplement featuring isolate cannabinol (CBN), a hemp-derived compound known to promote healthy sleep. While research into CBN, like CBD and many other cannabinoids, is in its infancy, CBN has been shown to increase total sleep time in rats.⁷ And since these gummies are made with CBN isolate, these gummies are an ideal sleep option for those who wish to avoid THC in their wellness routines. 

We're Here to Help 

Knowing the science behind melatonin and CBD gummies can help with making informed product purchases. Realizing the different types of CBD products and the importance of quality is equally important. 

At CBDistillery, we stand behind our products. Verified third-party testing and Certificates of Analysis for each individual product batch give you confidence in what you’re buying. And if you have questions about which product is right for you, you can check out more than 47,000 verified customer reviews or reach out to our customer service professionals. Please don't hesitate to contact us today with any concerns. 

If you have medical concerns, please consult your healthcare provider before using sleep gummies so your provider can advise you about your unique medical needs.

References

1. U.S. Centers for Disease Control and Prevention. (2024, May 15). FastStats: Sleep in Adults.https://www.cdc.gov/sleep/data-research/facts-stats/adults-sleep-facts-and-stats.html
2. Bruni O, Ferini-Strambi L, et al. (2021) Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. 13(2) Nutrients 530. 
3. Vaillancourt R, Gallagher S, Cameron JD, Dhalla R. Cannabis use in patients with insomnia and sleep disorders: Retrospective chart review. Can Pharm J (Ott). 2022 Apr 15;155(3):175-180. doi: 10.1177/17151635221089617. PMID: 35519083; PMCID: PMC9067069.
4. Babson KA, Sottile J, Morabito D. Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Curr Psychiatry Rep. 2017 Apr;19(4):23. doi: 10.1007/s11920-017-0775-9.
5. Fatemeh G, Sajjad M, Niloufar R, Neda S, Leila S, Khadijeh M. Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials. J Neurol. 2022 Jan;269(1):205-216. doi: 10.1007/s00415-020-10381-w.
6. Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. PLoS One. 2013 May 17;8(5):e63773. doi: 10.1371/journal.pone.0063773. PMID: 23691095; PMCID: PMC3656905.
7. Arnold, J.C., Occelli Hanbury-Brown, C.V., Anderson, L.L. et al. A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats.Neuropsychopharmacol. 50, 586–595 (2025). https://doi.org/10.1038/s41386-024-02018-7