What Are The Side Effects Of CBD?

Cannabidiol (CBD) is one of the 60 naturally occurring cannabinoids found in a cannabis plant. Unlike Tethrahydocannabdiol (THC), known for its psychoactive elements, CBD is non-intoxicating and can offer relief and 25mg CBD Capsules from Hemp CBD Oil at The CBDistillerybenefits without the disconcerting feelings of lethargy or dysphoria. The majority of information on the Internet today, highlights the potential benefits of CBD, but are there known side effects that users should be aware of and is there a limit to how much CBD one person can safely consume?

The Potential Side Effects of CBD

Multiple studies, published as early as 1980, suggest that CBD has minimal side effects and is overall safe for consumption. Nonetheless, consumers should be made aware of any known, potential drawbacks of something you are putting in your body. Below, we discuss the findings from each recorded study and review on the safety and known side effects of CBD.

1980 Study in Pharmacology

On January 3, 1980, Pharmacology published their findings conducted during a study in which they tested eight healthy volunteers and 15 patients with epilepsy, looking at the side effects of CBD when consumed daily for a month. Their reported conclusions were, ‘All patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination.’

International Journal of Neuroscience

In 1986, oral doses, ranging from 100 to 600 mg per day of cannabidiol were given to 5 patients with dystonic movement disorders. In addition to recording specific benefits, this study also uncovered mild side effects of CBD such as hypotension, dry mouth, psychomotor slowing, lightheadedness, and sedation. It is also noteworthy, that during this study 2 patients given CBD in doses over 300 mg per day seemed to aggravate their Parkinson’s symptoms. Yet in 2014 a separate paper described how CBD significantly improves the lives of those with Parkinson’s disease.

Safety and Side Effects of Cannabidiol

Most recently in 2011, a review on the safety and side effects of cannabidiol, found that CBD might interfere with the hepatic drug metabolism, alteration of in vitro cell viability, decreased fertilization capacity or the reduced activity of p-glycoprotein. Has a pharmacist or doctor ever told you not to drink or eat grapefruit while taking a prescription medication? Grapefruit and CBD have a similar effect on P450, an enzyme found in the liver, which metabolizes different kinds of drugs in the human body. If taken in large doses, CBD can inhibit the metabolizing properties of P450, temporarily neutralizing the effects of other medicinal products in the body’s system. This side effect is also responsible for why cannabidiol counteracts the effects of THC.

2006 Study Argentinian Study

In 2006 a group of scientist hypothesized that there are cannabinoid receptors in human’s salivary glands. In fact, their hypothesis was correct, which is most likely the reason that one of the previously discovered side effects of CBD is what’s commonly known as cotton-mouth. When CBD interacts with the endocannabinoid system, it inhibits the secretion of saliva, thus leaving some users with a dry sensation in their mouth.

Can you overdose on CBD?

Cannabidiol and other cannabinoids are known to be non-toxic, with no known fatal overdose levels ever reported. The previously mentioned study from 2011 indicated that chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. The Department of Health and Human Services states, ‘no signs of toxicity or serious side effects have been observed following chronic administration of cannabidiol to healthy volunteers (Cunha et al., Pharmacology 21:127-185, 1980), even in large acute doses of 700 mg/day (Consroe et al., Pharmacol, Biochem, Behav. 40:701-708, 1991).’

As you can see, there is evidence that supports CBD being a safe substance with minor side effects. We want to hear from you. Have you ever experienced side effects from using CBD? Please leave comments below.

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37 thoughts on “What Are The Side Effects Of CBD?”

  1. I actually ended up in the hospital from having two cookies after a Thanksgiving dinner several years ago. I was so lethargic that when I vomited while lying on the bathroom floor, I was unable to move myself away from the vomitus and it plugged up my nose. I also was quite hypothermic. I was Medi-vacced off the island to the mainland hospital, where I was placed under a tent with warm air blowing on me for over 4 hours. All in all, I was in the hospital approximately 20 hours at a cost of over $24,000.

    No one else at the dinner was in any way incapacitated. I am unable to consume much at ALL without extreme nausea–a side effect not listed in the above article.

    1. Hi Roberta,

      I am sorry to hear about this experience you had. Was there THC in the cookies you consumed?

      This article references scientific studies that specifically look at the side effects of just CBD. Cannabis products affect every one differently, but based on the referenced studies, nausea is not one of the known side effects of CBD.

      Thank you for your comment and please let us know if we can answer any additional questions.

      1. I have been using CBD oil daily for over a year and have never had a side effect. I have a movement disorder and chronic pain from muscles spasms. These keep me awake. Before bed a vape cbd and it helps me to fall asleep a lot easier than before I started using it.
        I’ve never heard of cbd in a cookie or edible without thc. A lot of thc can cause nausea but this story sounds like the cause of illness was from another source.

        1. I agree, I am thinking that maybe something during the Thanksgiving dinner might have been the cause. Things just don’t add up in that story with the properties of what CBD does / can do, especially considering it has anti-nausea properties.

    2. Yes it sounds to me like the cookies you ate were marijuana edibles I have a gluten intolerance and rhumatoid arthritis and I have been using CBD oils orally for 2+ months now and I am amazed at how my ***** **** and ***** ***** (from menopause) have almost completely subsided. I do not use products containing THC and have been warned about edibles and their side effects if you are not a a regular user. CBD by itself is what you should be using

      1. Hi Stacey,
        I too have gluten intolerence and RA, plus Fibro. I am new to CBD. I purchased a CBD tincture & tried a few drops under my tongue 2 or 3 times & didn’t feel anything. May I ask how much you use & how long it takes to work?? If you don’t wish to comment here, you can email me at sherri.woodward15@gmail.com.

        1. The key for me was to use “full spectrum” CBD made from the pot plant, not the “isolate” from hemp. I’ve heard people get good results from 10-15mg /day. Personally I take 25, but I am heavy. It works quickly, but also builds up over time.

    3. Are you sure the cookies you ate contained only CBD and not THC? I have never heard of “edibles” made with pure CBD and am surprised you were affected like this if they were. I am sorry for your horrrlible experience.

    4. Im sorry to hear that, but unfortunately that is a good possibility, People who generally don’t ingest think they can handle it, simply put, inhalation absorption rate is about 15% and goes directly into the blood stream, and to the brain, where ingestion has a 40% absorption rate, goes through the liver before the blood stream and gives you a body stoning, as well as whatever you ingest with it is amplified, ex. one beer is like 3 to 7 beers, or one coffee is like 3 to 7. All that is good is that you can’t die, but you can be extremely sick.

    5. CBD candy made me extremely sick with nausea and diarrhea. Experienced loss of bowel control and severe intestinal cramping for hours.

    6. Sounds like those cookies had more than just cbd in it. I have had similar effects off marijuana cookies. I have consumed cbd at high levels daily for a couple years and suffer nothing like u described. I know everybody is effected differently by stuff, but I find it hard to believe it was laced with cbd only and it gave those effects.

  2. I have hypertension. In early stages of finding out i had hypertension and getting prescriptionsfor hypertension i was a mess. My body was in panic mode. I finally also started to try local cbd- low levels of of thc. I went in for a check up after a few weeks of being prescribed medication. The Dr was impressed with how calmer i seemed. I didn’t tell him about cbd-thc though lol. i thought i would keep that a secret since some Drs probably see it as a no no since they might get paid money by pharmaceutical companies. I believe cbd helped hypertension not the other way. I had the problem before i tried cbd. I will not claim cbd will cure hypertension but i do believe with medication it will help someone with hypertension.

  3. What if any are the side affects using the salve? Does it linger in your blood stream so that if you have a lab tests done for a possible job, it shows up as having taken drugs?

    1. Hi Gay, Our Isolate has absolutely no THC and our Tinctures contain less than 0.3%. However, We are unable to legally state whether or not one of our customers will pass a drug test for any of our products. If that is a concern, I would recommend doing some further research at ProjectCBD.org, before making the decision to consume any CBD products. Please feel free to email sales@thecbdistillery.com if you have any additional questions 🙂

  4. I think Roberta ingested some cannabis infused cookies and couldn’t handle it. (Possibly just before writing her comment)
    That experience had nothing to do with cbds.
    Where were her friends and family this whole time? She was allowed to lay in a pile of her own vomit long enough for it to plug her nose?
    How did she get hypothermia indoors? She needed a medivac?
    I would totally disregard her comment. Still can’t tell if it is satire.

  5. I tried the medical marijuana which had the THC in it and did not like the feeling. Then I found this web site with pure CBD and have used CBD regularly. I was on five different pain relieving medications which messed up my liver. CBD has saved me from further ***** ****** as well as *********** my ****. The only side effect I have is dry mouth. I highly recommend this product and CBDistillary!

  6. There is a rare condition known as CHS cannabis hyperemesis syndrome and if you are unfortunate enough to have it then cbd can cause it to go into effect. Happened to me recently had to go to ER to get fluids IVed until I quit vomiting. But it was still worth all the benefits it has given me.

  7. With CBD from hemp I get sleepy if I take too much. I also experience cognitive slowing at moderate to high doses With lower doses I do get dry mouth. I use it mainly for anxiety (a long term anxiety disorder previously managed with antidepressants). My only complaint is the tolerance that builds up over time. This makes it hard to figure out the right dose. CBD has saved me from having to go on Benzodiazepines.

  8. I have had chronic pain for the last 20 years come this September. I am currently on five different pain meds. I am going to check with my neurologist regarding CBD and side effects with those meds. Not meds that I can just stop taking. Five surgeries have kept me upright but now with another MRI looming and increasing pain, I am ready to try almost anything!! Thanks for reading. If you have any ideas, I am ready to listen.

    1. Hi Pat, we are not legally able to give dosage advice. If you have any additional questions about a specific product, please email sales@thecbdistillery 🙂

    2. I use the 1000mg in a 30ml bottle that I make myself using the CBD isolate powder by mixing the PG and powder, then I double boil it for about 20 minutes then I add in VG and flavoring. The bottle I use has a little glass stick in it that I use to place some under my tongue. I typically do about 2-3 dips of the stick under my tongue every 4-5 hours and I am perfectly great. My back pain has completely gone away ever since using it and I have had it for 15+ years.

  9. I have yet to really see any of the above (or any other) side effects with pure CBD isolate.

    However even with the smallest amount of THC I have seen many of them. Still nothing serious or deterring… Except the negating effects being that I’m still using pain killers at the moment. With regular cannabis/products with THC, it would almost cancel out most of the relief from my pain killers & require me to take a new dose (which is really not good when I’m sure like everyone else, they don’t give you an adequate amount or you are just trying to stay low as possible as I am). With CBD isolate however this is no where near as intense… If for comparison cannabis/THC’s negating effect or strength was a 10, then CBD Isolate’s would be less then one for me.

    I would get not only pretty strong cotton mouth from cannabis/THC (which dry mouth leads to bad oral health & decay), but it also gets me really congested & plugged up in my nose almost like an allergy(I have a deviated septum and could be the cause). CBD does not give me any dry mouth, and is the opposite & makes my nose runny(which is one “side effect” I can say as possibly having seen)… However though, it is actually a Very Helpful “side effect” when I am congested from allergies or something.

    CBD isolate dabs can also give me a flash of sweat, but I believe that is primarily due to the method of intake because not always happens & primarily if I cough hard. Also I need to mention that it is just one sweating flash episode & not continuous.

    The only reason I do not use regular cannabis/THC is because I do not like any kind of inebriation & ever since stopping the everyday social as a young man, it has been too intense when trying again… even with the smallest amounts possible & thus just lost my tolerance for it. CBD isolate however has made it so I can again partake recreationally with friends by putting a little bit of isolate on right before my turn to partake.

    Most Importantly! CBD isolate has given me back a fair amount (not as much, but still a god send) of the best benefit of cannabis for me… The increased appetite & anti-nausea! I have severe stomach problems and never feel hunger, if anything my body skips any of that & goes straight to puking bile and trying to digest itself after only 4hrs w/o food. Which has lead to extreme low weight problems ever since a pre-teen child. Though not as intense of an increased desire to eat as cannabis/THC, it is a benefit that is still there and has possibly saved my life. If someone were to have the opposite of me and have obesity problems & problems eating too much, then it might add to that… Though No Where Near Regular Cannabis/THC & so possibly still a “side effect” that doesn’t out weigh other benefits the person may recieve.

    So far the only possible “side effects” I can really see some people might have from pure CBD, are also possible benefits to others such as myself.

    Sorry so long, Thank You.

  10. I do get an upper respiratory “allergic” reaction sometimes when I take cbd oil. Some brands cause it more than others. If I take too much, it will give me an allergy-like headache. Reminds me of seasonal allergy symptoms. But the relief it gives me for symptoms of chronic Lyme and the long term damage caused from mold exposure is immeasurable. It really works on all of my nerve issues, including anxiety.

  11. I tried using your CBD Oil through advice of my 20 yr old son going to college to get his doctorate in Physical Therapy. His professors teach alternative meds.
    I was hit head on by a drunk driver in 93 have had over 30 surgeries. I was sheduled to have my spine fused next month from L2-S1. I stopped using CBD Oil because I had read being on it prior to surgery could cause a problem with the blood clotting.

  12. I have RA and I have been scintillating on the CBD but I’m not sure which one to use I didn’t realize it came in different ways…ease can you tell me which product one would use for RA?

    1. Hi Kristi,

      Thank you for your comment. Legally, we are unable to make product recommendations based on a certain condition, but would highly suggest doing some research at ProjectCBD.org. If you have specific questions regarding our products, please feel free to send us an email (sales@thecbdistillery.com) and we would be happy to assist you further.

  13. I’m so confused about how to dose CBD. Most of the studies I see, including those referenced here, are using hundreds of milligrams. It’s almost impossible to get any real guidance on how to dose. I’ve found little pain relief from doses ranging from 1-100 mg/day and I don’t know very many people who could possibly afford to take more than that a day over the long term due to the high cost. The disconnect between the dosing in the literature and the products commercially available is always frustrating.

  14. I use the CBD oil 250mg 5 drops under the tongue in the morning and evening. The only problem I have is it gives me a runny stool. I had breast cancer 3 1/2 years ago and I have to take a pill called anastrozole and it attacks the muscles and joints and the CBD oil helps relieve my pain.

  15. How to sensibly buy LEGAL cbd oil online? Because I got a letter saying customs has confiscated my package two times already and i’m pissed.

  16. Hi,

    I use CBD for my chronic pain and my neuropathy and it helps within minutes, I’ve thought about trying a tincture because I’ve been told that it would also help with my pain. I’m retired, yet I get random drug tested because I get monthly pain meds. Will I test positive if I use your tincture ?

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