Cannabidiol (CBD) is one of the 60 naturally occurring cannabinoids found in a cannabis plant. Unlike Tethrahydocannabdiol (THC), known for its psychoactive elements, CBD is non-intoxicating and can offer relief and benefits without the disconcerting feelings of lethargy or dysphoria. The majority of information on the Internet today, highlights the potential benefits of CBD, but are there known side effects that users should be aware of and is there a limit to how much CBD one person can safely consume?
The Potential Side Effects of CBD
Multiple studies, published as early as 1980, suggest that CBD has minimal side effects and is overall safe for consumption. Nonetheless, consumers should be made aware of any known, potential drawbacks of something you are putting in your body. Below, we discuss the findings from each recorded study and review on the safety and known side effects of CBD.
1980 Study in Pharmacology
On January 3, 1980, Pharmacology published their findings conducted during a study in which they tested eight healthy volunteers and 15 patients with epilepsy, looking at the side effects of CBD when consumed daily for a month. Their reported conclusions were, ‘All patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination.’
International Journal of Neuroscience
In 1986, oral doses, ranging from 100 to 600 mg per day of cannabidiol were given to 5 patients with dystonic movement disorders. In addition to recording specific benefits, this study also uncovered mild side effects of CBD such as hypotension, dry mouth, psychomotor slowing, lightheadedness, and sedation. It is also noteworthy, that during this study 2 patients given CBD in doses over 300 mg per day seemed to aggravate their Parkinson’s symptoms. Yet in 2014 a separate paper described how CBD significantly improves the lives of those with Parkinson’s disease.
Safety and Side Effects of Cannabidiol
Most recently in 2011, a review on the safety and side effects of cannabidiol, found that CBD might interfere with the hepatic drug metabolism, alteration of in vitro cell viability, decreased fertilization capacity or the reduced activity of p-glycoprotein. Has a pharmacist or doctor ever told you not to drink or eat grapefruit while taking a prescription medication? Grapefruit and CBD have a similar effect on P450, an enzyme found in the liver, which metabolizes different kinds of drugs in the human body. If taken in large doses, CBD can inhibit the metabolizing properties of P450, temporarily neutralizing the effects of other medicinal products in the body’s system. This side effect is also responsible for why cannabidiol counteracts the effects of THC.
2006 Study Argentinian Study
In 2006 a group of scientist hypothesized that there are cannabinoid receptors in human’s salivary glands. In fact, their hypothesis was correct, which is most likely the reason that one of the previously discovered side effects of CBD is what’s commonly known as cotton-mouth. When CBD interacts with the endocannabinoid system, it inhibits the secretion of saliva, thus leaving some users with a dry sensation in their mouth.
Can you overdose on CBD?
Cannabidiol and other cannabinoids are known to be non-toxic, with no known fatal overdose levels ever reported. The previously mentioned study from 2011 indicated that chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. The Department of Health and Human Services states, ‘no signs of toxicity or serious side effects have been observed following chronic administration of cannabidiol to healthy volunteers (Cunha et al., Pharmacology 21:127-185, 1980), even in large acute doses of 700 mg/day (Consroe et al., Pharmacol, Biochem, Behav. 40:701-708, 1991).’
As you can see, there is evidence that supports CBD being a safe substance with minor side effects. We want to hear from you. Have you ever experienced side effects from using CBD? Please leave comments below.
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