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CBD and Mushrooms: Individual Benefits & How They Work Together

Written By Ellese Symons Oct 7th 2022
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Most CBD users select hemp-derived health and wellness products based on their cannabinoid concentrations alone. Some prefer products made with a single cannabinoid (CBD isolate), while others prefer using broad spectrum or full spectrum CBD. Although most report positive results, many CBD users are also taking advantage of hemp-derived tinctures, capsules, and gummies made with ingredients you might not expect. At CBDistillery®, you'll find a selection of products made with enhanced concentrations of some of the plant's most impactful minor cannabinoids and functional supplements.

Combining the therapeutic potential of natural ingredients is nothing new. The first written record dates back centuries, nearly 5000 years (Petrovska, 2012). We've learned a lot since then, enough to understand how the active components in some extracts can complement or even enhance specific attributes of another. While you might be a bit surprised to find CBD paired with mushrooms, we think you'll be impressed. Once you know their individual contributions, you'll also understand why our expert botanists decided to combine our full spectrum extract with Lion's Mane, Cordyceps, Reishi, and Chaga.

Could You Benefit From Mushrooms?

There are about 14,000 different types of mushrooms. Thousands are edible, and many are prized for benefits exceeding their nutritional value, their adaptogenic properties. (Chang & Wasser, 2017). Adaptogens are substances that help upregulate or downregulate stress responses as needed in a way that helps restore equilibrium (homeostasis). Researchers credit the health and wellness potential of adaptogenic mushrooms to the interaction of their various flavonoids, terpenes, polysaccharides, terpenoids, and lectins with the hypothalamic-pituitary-adrenal axis (HPA) through several molecular channels (Chugh et al., 2022). High-quality extracts are typically sourced from the mushroom's fruiting bodies, its stalks, caps, and gills.

Some people use functional mushroom blends to help support overall health and wellness; others choose mushroom supplements based on their potential benefits for specific aspects of physical, mental, or emotional well-being as needed. For example, people often gravitate toward the adaptogenic properties of Lion's Mane for its potential to support cognitive function, mental clarity, focus, and creative processes (Saitsu et al., 2019). For a calming, soothing effect, Reishi could be the better choice (Ali et al., 2016), and many people choose Cordyceps supplements for energy and stamina (Das et al., 2021).

How Do the Potential Benefits of CBD Compare?

CBD also supports overall health and wellness. Based on the feedback of nearly 2000 CBD users, most report positive results using hemp-derived CBD for better sleep, relaxation, mild or temporary anxiety, and for pain, stiffness, and inflammation after physical activity. Although most of the supporting evidence is based on laboratory tests and animal studies, we know CBD interacts with several molecular targets, including the receptors of the serotonin, GABA, dopamine, and endocannabinoid systems (ECS) (Brunt & Bossong, 2020). As the body's largest regulatory system, ECS signaling impacts nearly every crucial function, including sleep cycle regulation, metabolic processes, and muscle movement (Mouslech & Valla, 2009).

Ideally, your body would make all the ECS messengers it needs to keep this communication system working efficiently. But life isn't always ideal. Numerous internal and external factors, including stress, can create a demand for ECS messengers that exceeds the available supply. CBD helps support ECS function in a way that promotes essential balance (homeostasis) (Sallaberry & Astern). Many cannabis researchers also believe the additional cannabinoids and terpenes in full spectrum (and broad spectrum) CBD contribute to an "entourage" effect that maximizes the contributions (and overall effect) of each active compound (Nahler et al., 2019).

Can I Take Mushroom Supplements and CBD Together?

Yes, you can definitely use mushrooms and CBD together to take full advantage of their synergistic effects. Now that you know the health and wellness potential of their individual contributions, you might even be tempted to pick up the first CBD product you find locally, grab a mushroom supplement, and test the waters. While there's no harm in trying a DIY approach, you may not get the results you're hoping for. The purity, potency, and overall quality of hemp-derived products and mushroom supplements can vary by brand. Instead of leaving your first experience to chance, consider some of the many ways you could benefit from CBDistillery® Functional Synergy Mushroom Capsules.

CBDistillery® Functional Synergy Focus Mushroom Capsules give you 300mg of Lion's Mane extract and 300mg of Cordyceps extract in every serving. You'll also get 15mg of full spectrum CBD and 15mg of CBG, a 1:1 CBD to CBG ratio selected for an enhanced entourage effect. We think you'll appreciate the positive impact of this proprietary blend of cannabinoids and natural terpenes on your energy levels, cognitive function, and focus.

CBDistillery® Function Synergy Unwind Mushroom Capsules are made with a completely different blend of functional mushrooms and cannabinoids, a combination selected to help you relax at the end of the day and get the rest you need for a better tomorrow. Each capsule gives you 300mg of Reishi extract, 300mg of Chaga extract, 15mg of full spectrum CBD, and 5mg of CBN (cannabinol), a cannabinoid known for its sleep-promoting potential.

Are You Ready to Experience the Many Potential Benefits of Functional Synergy?

CBDistillery® Functional Synergy Focus Blend marries the potency maximizing potential of CBG with Lion's Main and Cordyceps, adaptogens selected for energy, stamina, and concentration. Our Functional Synergy Unwind Blend features the relaxing, sleep-promoting potential of CBN, plus Chaga and Reishi, adaptogens selected for rest, relaxation, and tranquility. We think you'll appreciate the combined health and wellness potential of full spectrum hemp extracts, pure cannabinoid isolates, and mushroom supplements. According to the results of our internal survey, 62% of people using multiple CBD products daily felt they were more effective together than using a single product alone. Although individual results can vary, and it can take time for your system to respond, most CBD users also report achieving their best results within 7-14 days of consistent use.

To learn more about supporting ECS function with CBD, visit CBDistillery® to read CBD 101 or download our Ultimate CBD User Guide, the #1 resource guide for CBD users. Then consider browsing the tinctures, gummies, drink mixes, and capsules featured in our Synergy Collection. You can shop with confidence knowing CBDistillery® products are third-party tested, and backed by a 60-day satisfaction guarantee. If you have a medical condition or take medication, please consult your healthcare provider before adding CBD or functional mushrooms to your daily routine.


Ali N, Muhammad A, et al. (2016) Anxiolytic-Like Activity of Ethanol Extract of Ganoderma Lucidum (Reishi) in Mice. 5(6) IJMRHS 57-60. PDF

Brunt T, Bossong M. (2020) The Neuropharmacology of Cannabidiol in Central Signaling Pathways. 55(4) ENJ 909-21. https://doi.org/10.1111/ejn.14982

Chang S, Wasser S. (2017) The Cultivation and Environmental Impact of Mushrooms. Environmental Science https://doi.org/10.1093/acrefore/9780199389414.013.231

Chugh R, Mittal P, et al. (2022) Fungal Mushrooms: A Natural Compound with Therapeutic Applications. 13, Front Pharmacol. https://doi.org/10.3389/fphar.2022.925387

Das G, Shin H, et al. (2021) Cordyseps Spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. 11, Front Pharmacol. https://doi.org/10.3389/fphar.2020.602364

Mouslech Z, Valla V. (2009) Endocannabinoid System: An Overview of Its Potential in Current Medical Practice. 30(2) Neuro Endocrinol Lett 153-79. PDF

Nahler, G, Jones T, et al. (2019) Cannabidiol and Contributions of Major Hemp Phytocompounds to the "Entourage Effect"; Possible Mechanisms. J Altern Complement Integr Med 70(5) PDF download

Petrovska B. (2012) Historical Review of Medicinal Plants' Usage. 6(11) Pharmacongn Rev 1-5. https://doi.org/10.4103/0973-7847.95849

Saitsu Y, Nisheide A, et al. Improvement of Cognitive Functions by Oral Intake of Hericium Erinaceus. Biomed Res 30(4) 125-31. https://doi.org/10.2220/biomedres.40.125

Sallaberry C, Astern L. (2018) The Endocannabinoid System, Our Universal Regulator. 34(6) JYI 48-55. https://www.jyi.org/2018-june/2018/6/1/the-endocannabinoid-system-our-universal-regulator