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In the Synergy Collection by CBDistillery®, you'll find a wide range of products made with an impressive selection of minor cannabinoids and functional supplements, ingredients selected to enhance specific attributes of our full spectrum (and broad spectrum) extracts. After receiving dozens of 5-star reviews in tincture form, our expert botanists have made a clear customer favorite even easier to add to your daily routine.
The latest addition to our Synergy Collection features the health and wellness potential of our Raw Synergy CBDA + CBD 1:1 Tincture presented in an easy-to-swallow softgel. If you've never tried this precise combination of cannabinoids, consider taking a few minutes to discover how you could benefit. If you're already a fan, you're sure to appreciate having a second option, a product that's great for home use or travel.
Hemp-derived CBDA is the acidic form of CBD (cannabidiol). But it's not the first cannabinoid produced in the plant. That distinction belongs to the "mother" of all cannabinoids, cannabigerolic acid (CBGA). As crops mature, naturally occurring enzymes convert CBGA to CBDA (cannabidiolic acid), CBCA (cannabichromenic acid), and THCA (tetrahydrocannabinolic acid). Over time, heat and sunlight convert these acidic cannabinoids to their "active" forms, CBG (cannabigerol), CBC (cannabichromene), THC (tetrahydrocannabinol), and CBD (Cai et al., 2020), through a process called decarboxylation.
Raw hemp extract typically contains relatively high amounts of CBDA. But most product manufacturers heat their oil to specific temperatures to speed decarboxylation and maximize CBD concentrations. While there was a time cannabis researchers believed acidic cannabinoids like CBDA had little to offer on their own, a growing body of evidence tells an entirely different story (Formato et al., 2020). Today, you'll find numerous reports suggesting CBDA could be just as beneficial as its non-acidic counterpart. Once you know how CBDA and CBD work in your body, it's easy to see why so many CBDistillery® customers appreciate their combined health and wellness potential.
CBD and CBDA have similar origins, but they work quite differently. CBD's molecular structure allows the cannabinoid to interact with the receptors of the largest regulatory system in your body, the endocannabinoid system (ECS) receptors CB1 and CB2, in a way that helps promote essential balance (homeostasis) (Sallaberry & Astern, 2018). Although CBDA is also a cannabinoid, it has little (if any) affinity with your ECS receptors. Instead, the acidic form of CBD has a direct impact on a receptor known as 5-HT1A, a serotonin system receptor.
Researchers believe CBDA's influence on 5-HT1A helps fine-tune the effects of CBD by inhibiting the function of COX-2 enzymes (Takeda et al., 2008). Researchers also believe CBDA's impact on COX-2 helps prevent the breakdown of the "bliss molecule" anandamide (Yang et al., 2008), an essential ECS messenger that plays a vital role in immune system function, transmitting signals between nerve cells, and promoting feelings of overall well-being (Self, 1999).
Full spectrum hemp extract contains all the additional cannabinoids, terpenes, flavonoids, and phytonutrients in the same ratios produced in the plant, including a small amount of CBDA. Of the three main product types, Many CBD users feel full spectrum products are more potent than similar options made with broad spectrum plant extracts and pure CBD isolate powder because of the way the combined effects of the plant's many minor cannabinoids and terpenes maximize the overall contributions of each plant component. It's a feature unique to cannabis researchers call an "entourage" effect (Nahler et al., 2019).
Our Raw Synergy CBDA + CBD Tincture and our new Raw Synergy CBDA + CBD Softgels give you the combined benefits of our high-quality full spectrum CBD oil and just enough CBDA extracted from the flowering buds of female hemp plants to achieve a 1:1 CBDA to CBD ratio. In addition to interacting with serotonin receptors and contributing to an enhanced entourage effect, current evidence suggests CBDA is easier for the body to utilize (Pellesi et al., 2018) and could also help improve CBD's absorption and retention (Wakshlag et al., 2020).
While our selection of high-quality tinctures will always be popular with CBD users who appreciate that type of versatility, they're simply not right for everyone, at least not 100% of the time. Whether you're a devoted Raw Synergy fan or considering your first purchase, there are plenty of reasons to consider adding a bottle of our new CBDA + CBD 1:1 Softgels to your order.
A one-dropper serving of our Raw Synergy Tincture gives you 17mg of CBDA and 17mg of CBD, provided you've shaken the bottle to blend the ingredients and measured accurately. When you choose our new Raw Synergy Softgels, you never have to worry about serving size consistency. We've done the work for you. With each softgel, you'll get a precise blend of hemp-derived cannabinoids in an amount that seems to work well for most CBD users.
CBD tinctures are typically sold in dark glass bottles to help protect the contents from sunlight (and cannabinoid degradation). While you might feel perfectly comfortable using a tincture at home, glass bottles are not ideal for travel. With softgels, you won't have to worry about dealing with the aftermath of leaks, spills, or broken glass. Plus, you'll have the option of slipping several servings into a discreet pill box or vitamin caddy.
Raw hemp extract has a robust terpene profile that translates to an equally strong flavor and aroma. If you're one of the many CBD users who appreciates the effects of full spectrum (or broad spectrum) hemp-derived products but aren't thrilled with the taste, softgels could be the better fit. With your concentrated plant extracts safely encased within a smooth gelatin shell, there's no earthy, grass-like flavor or objectionable odor to contend with.
When browsing the submissions of CBDistillery® customers commenting on the effects of our Raw Synergy CBDA & CBD Oil 1:1 Tincture, you'll see dozens of positive remarks and 5-star reviews. Upon further evaluation, you'll find an impressive number of entries from people reporting favorable results for better sleep, relaxation, discomfort after physical activity, feelings of overall well-being, and more.
Our new Raw Synergy CBDA & CBD Softgels offer the same robust terpene profile unique to raw hemp extract you'll find in our Raw Synergy tincture, but in a convenient, highly portable form. We think you'll appreciate how their precise blend of hemp-derived cannabinoids fits into your on-the-go lifestyle. You can shop with confidence knowing every product we offer is rigorously tested, quality assured, and backed by a 60-day risk-free satisfaction guarantee.
To learn more, visit CBDistillery® to find answers to frequently asked questions, read industry studies, or browse our CBD blog. If you're interested in the health and wellness potential of our hemp-derived cannabinoids but not quite sure where to start, consider scheduling a consultation with a product expert.
Cai C, Wang Y, et al. (2020) Ionic Liquids Simultaneously Used as Accelerants, Stabilizers and Extractants for Improving the Cannabidiol Extraction from Industrial Hemp. 155(27) Industrial Crops and Products. https://doi.org/10.1016/j.indcrop.2020.112796
Formato M, Crescente G, et al. (2020) Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Clinical Research. 25(11) Molecules 2638. https://doi.org/10.3390/molecules25112638
Nahler, G, Jones T, et al. (2019) Cannabidiol and Contributions of Major Hemp Phytocompounds to the "Entourage Effect"; Possible Mechanisms. J Altern Complement Integr Med 70(5) PDF download
Pellesi L, Licata M, et al. Pharmacokinetics and Tolerability of Oral Cannabis Preparations in Patients with Medication Overuse Headache (MOH) – a Pilot Study. 74(11) Eur J Clin Pharmacol 1427-36. https://doi.org/10.1007/s00228-018-2516-3
Sallaberry C, Astern L. (2018) The Endocannabinoid System, Our Universal Regulator. 34(6) JYI 48-55. https://www.jyi.org/2018-june/2018/6/1/the-endocannabinoid-system-our-universal-regulator
Self D. (1999). Anandamide: A Candidate Neurotransmitter Heads for the Big Leagues. 2(4) Nature Neuroscience 303-4. https://doi.org/10.1038/7210
Takeda S, Misawa K, et al. (2008) Cannabidiolic Acid as a Selective Cyclooxygenase-2 Inhibitory Component in Cannabis. 36(9) Drug Metab Dispos 1917-21. https://doi.org/10.1124/dmd.108.020909
Wakshlag J, Schwark W, et al. (2020) Pharmacokinetics of Cannabidiol, Cannabidiolic Acid, Δ9-Tetrahydrocannabinol, Tetrahydrocannabinolic Acid and Related Metabolites in Canine Serum After Dosing with Three Oral Forms of Hemp Extract. 7, Front Vet Sci 505 https://doi.org/10.3389/fvets.2020.00505
Yang H, Zhang J, et al. (2008) COX-2 Oxidative Metabolism of Endocannabinoids Augments Hippocampal Synaptic Plasticity. 37(4) Mol Cell Neurosci 682-95. https://doi.org/10.1016/j.mcn.2007.12.019